Stewart Shuman Selected Research

Vaccinia

1/2017	Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB.
4/2014	Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.
2/2013	Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification.
1/2012	Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain.
10/2011	Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
11/2008	Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site.
11/2008	Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.
6/2008	Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry.
4/2008	Structure-function analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase.
12/2007	Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly.

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Stewart Shuman Research Topics

Disease

25	Vaccinia 01/2017 - 02/2002
11	Infections 01/2021 - 10/2006
7	Starvation 01/2020 - 10/2015
4	Virus Diseases (Viral Diseases) 01/2018 - 01/2007
3	Tuberculosis (Tuberculoses) 06/2021 - 01/2011
3	Neoplasms (Cancer) 05/2017 - 06/2006
3	Bites and Stings (Sting) 05/2017 - 08/2013
1	Coccidioidomycosis 01/2021
1	Leprosy (Hansen's Disease) 01/2017
1	Hypersensitivity (Allergy) 02/2013
1	Poxviridae Infections 01/2012
1	Smallpox (Variola) 10/2011
1	Inborn Genetic Diseases (Disease, Hereditary) 06/2009
1	Chromosome Breakage 05/2007
1	Kaposi Sarcoma (Kaposi's Sarcoma) 04/2005
1	Breast Neoplasms (Breast Cancer) 10/2004

Drug/Important Bio-Agent (IBA)

15	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 03/2003
9	Type I DNA Topoisomerases (Topoisomerase I)IBA 02/2013 - 03/2003
8	Phosphates (Orthophosphate)IBA 01/2020 - 01/2004
7	Proteins (Proteins, Gene)FDA Link 01/2017 - 10/2006
5	EnzymesIBA 01/2021 - 02/2002
5	Amino Acids FDA Link 01/2019 - 02/2002
5	RNA (Ribonucleic Acid)IBA 01/2018 - 02/2002
5	Antiviral Agents (Antivirals)IBA 08/2013 - 11/2008
4	Pharmaceutical PreparationsIBA 06/2021 - 05/2004
3	thyroglobulin peptide (2495-2511)IBA 11/2018 - 01/2017
3	cyclic guanosine monophosphate-adenosine monophosphateIBA 05/2017 - 08/2013
3	anticodon nucleaseIBA 06/2012 - 01/2011
3	Transfer RNA (tRNA)IBA 06/2012 - 08/2007
3	DNA Ligases (Ligases, DNA)IBA 01/2011 - 12/2007
3	Ligases (Synthetase)IBA 06/2009 - 02/2002
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2004 - 01/2002
2	Alanine (L-Alanine)FDA Link 11/2018 - 04/2003
2	Transcription Factors (Transcription Factor)IBA 11/2018 - 01/2017
2	InterferonsIBA 05/2017 - 08/2013
2	Phosphotransferases (Kinase)IBA 04/2014 - 02/2002
2	VaccinesIBA 04/2014 - 10/2011
2	Virulence Factors (Pathogenicity Factors)IBA 04/2014 - 10/2011
2	Z-Form DNA (Z-DNA)IBA 01/2012 - 10/2011
2	CytokinesIBA 10/2011 - 10/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2011 - 10/2006
2	Interleukin-6 (Interleukin 6)IBA 11/2008 - 10/2006
2	ApoenzymesIBA 11/2008 - 03/2006
2	MethyltransferasesIBA 11/2008 - 04/2008
2	Viral ProteinsIBA 12/2007 - 10/2006
2	Tyrosine (L-Tyrosine)FDA Link 04/2005 - 02/2002
1	Long Noncoding RNAIBA 01/2020
1	Phosphate Transport Proteins (Phosphate Transporter)IBA 01/2018
1	EndoribonucleasesIBA 01/2018
1	GlycerophosphatesIBA 01/2018
1	Immune Checkpoint InhibitorsIBA 05/2017
1	Neoplasm Antigens (Tumor Antigens)IBA 05/2017
1	ZincIBA 01/2017
1	ElementsIBA 01/2017
1	ribonuclease HIIBA 01/2017
1	AcidsIBA 01/2017
1	Deoxyribonuclease I (Nickase)IBA 01/2017
1	Acid PhosphataseIBA 10/2015
1	Interferon Type IIBA 04/2014
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 04/2014
1	vadimezanIBA 08/2013
1	LigandsIBA 08/2013
1	Lysine (L-Lysine)FDA Link 02/2013
1	Lys Transfer RNAIBA 01/2012
1	Toll-Like Receptor AgonistsIBA 01/2012
1	Viral RNAIBA 01/2012
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2011
1	Interferon-betaIBA 11/2008
1	Guanosine Triphosphate (GTP)IBA 04/2008
1	Mitoxantrone (Novantrone)FDA LinkGeneric 12/2007
1	EndonucleasesIBA 05/2007
1	Interleukin-12 (IL 12)IBA 10/2006
1	LipopolysaccharidesIBA 10/2006
1	Poly I-CIBA 10/2006
1	Cytarabine (Cytosar-U)FDA LinkGeneric 10/2006
1	AntigensIBA 10/2006
1	NF-KappaB Inhibitor alphaIBA 10/2006
1	adenosine N(1)-oxideIBA 10/2006
1	Interleukin-10 (Interleukin 10)IBA 10/2006
1	Interferon-alpha (Interferon Alfa)IBA 10/2006
1	Interleukin-1beta (Interleukin 1 beta)IBA 10/2006
1	A-Form DNA (A-DNA)IBA 06/2006
1	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 06/2006
1	exodeoxyribonuclease IIIIBA 06/2006
1	DNA AdductsIBA 06/2006
1	PoisonsIBA 06/2006
1	MicroRNAs (MicroRNA)IBA 04/2005
1	AcylphosphataseIBA 10/2004
1	carboxy-terminal domain phosphataseIBA 10/2004
1	NucleotidesIBA 09/2004
1	benzo(c)phenanthreneIBA 05/2004
1	Intercalating AgentsIBA 05/2004
1	AnthracyclinesIBA 05/2004
1	NogalamycinIBA 05/2004
1	8-hydroxyadenineIBA 10/2003
1	pyreneIBA 10/2003
1	8-hydroxyguanineIBA 10/2003
1	2-Aminopurine (2 Aminopurine)IBA 10/2003

Therapy/Procedure

2	Therapeutics 01/2021 - 05/2017
1	Immunotherapy 05/2017